Something new for cat FIPV
AS we all know there are three ways to cure the cat FIPV
First is gs 376
But it has a lot og shortcoming,such as hard to cross the blood-brain barrier and has little effect on entering the eye and nerve.
Second, the 3cl
Protease is too complex too many sites that can be mutated, such as n25s, a252s, k260n, and these amino acids are mutated, which makes gc376 useless.
· Then there is GS441524
GS441524 to pass through the blood brain is much stronger,it only has a few mutations in the RDRP of the strain, such as D802, the exonuclease of the strain recognized this position and replaced it with a fake, and then he repeats the ntp, which will produce resistance, less than 10 percent of the time. It won't work when fipv is resistant to 441. This shows that 441 may still relapse after 12 weeks of treatment. Another drawback is the skin will rot. But rotting skin is easy to cure.
The last one is 2801 powder.
There are a lot of people wonder that which is better, 2801 or 441? As far as I'm concerned, toxicity to cats was observed at high doses, and its potential chronic side effects remain unknown 2801 is very short lived so we can’t identify it side effects,and many other things.maybe it’s better than 441524 but according to the current situation I suggest to use GS-441521 to cure cat FIP.
Relapse rates are low if the treatment regimen is followed and the cycle is strictly followed. And symptomatic infusion therapy can greatly reduce the mortality of cats. For the recovered cats should pay attention to daily feeding and management, properly taken care of the cat's life and ordinary cats are similar.the cat transmits abdomen to have a relapse to want according to the specific circumstance of cat and decide, some cat won't be infected again after cure, and some cat because treatment is not complete, cause course of disease aggravation, this can call "have a relapse". So if the cat is diagnosed as cat abdomen, try to use 441 and other drugs to control the disease, in the control of the disease within half a month can not stop the needle.
But recently, a new drug is appears,KP-01!Does kp-01 work?
First of all, the following views are personal
The duration of this drug is short, the clinical experiment experience is not enough, the papers on this drug and the description of side effects are few, and the safety needs to be studied. Secondly, he said that the dose is fixed, the amount of body weight is so much,The reason why 441 varies according to weight is because there are a lot of clinical trials where the dose is fixed and I think it's because there are not enough trials, and people have to take the dose, and children and adults have to take the dose differently.
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